Top 10 HIPAA-compliant electronic signature platforms

Sign, track, and store contracts — without the complexity of CLM.
See why healthcare teams choose Signeasy for secure, HIPAA-compliant eSignatures.
Rachana Chotia
Rachana Chotia
December 11, 2024
2024-12-11
Updated on
December 15, 2025
2024-12-11
2024-12-11
15
 min read
Rachana Chotia
Rachana Chotia
December 11, 2024
2024-12-11
 • 
15
 min read
Top 10 HIPAA-compliant electronic signature platforms
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Key Takeaway

  • HIPAA-compliant eSignature platforms protect patient data while speeding up healthcare workflows, from consent forms to treatment authorizations.
  • Healthcare standards demand more than basic eSignatures. Look for encryption, audit trails, multi-factor authentication, and a signed Business Associate Agreement (BAA).
  • Penalties for non-compliance are steep. HIPAA violations range from $100 to $50,000 per incident, with annual maximums reaching $1.5 million per violation category.
  • The top 10 platforms reviewed include Signeasy, Docusign, PandaDoc, Dropbox Sign, Adobe Acrobat Sign, and five others. Each was evaluated for security, usability, and healthcare integration.
  • Signeasy stands out with AI-powered contract insights, reusable templates, comprehensive audit trails, full mobile and tablet support, and seamless EHR integration, making it ideal for mid-sized to enterprise healthcare organizations.

Dealing with patient paperwork and maintaining compliance with HIPAA regulations is one of the biggest, most time-consuming challenges in healthcare.

The constant cycle of printing, scanning, faxing, and filing simply wastes valuable time and it also increases the risk of errors and exposure for sensitive patient data.

The good news is that you don't have to choose between keeping patient information safe and running an efficient office.

Modern, HIPAA-compliant eSignature solutions are designed to end that endless paper trail. These digital tools let patients and staff sign important forms instantly and securely, right from any computer or phone. Your team's time gets freed up to focus on patient care while every signature meets HIPAA's strict privacy and security rules.

To help your practice find the right fit, we've put together the essential compliance information you need and reviewed the 10 best options available today.

What we'll cover in this guide:

  • Our list of the top 10 HIPAA-compliant eSignature platforms
  • Why HIPAA compliance matters for eSignatures and what requirements your solution must meet
  • How to choose the right platform and avoid common compliance mistakes
  • Real-world use cases and best practices for secure healthcare document workflows
How we sourced our data

To provide accurate recommendations, we reviewed each platform's official website, security documentation, compliance certifications, and HIPAA-specific features. We also analyzed verified user reviews from G2 and Capterra, examining feedback from healthcare organizations and regulated industries.

Our evaluation focused on encryption standards, audit trail capabilities, Business Associate Agreement (BAA) availability, ease of use, and integration with healthcare systems. This approach saves you hours of research and helps you find secure electronic signature software for healthcare that meets your compliance and operational needs.

Quick overview of the top 10 HIPAA compliant eSignature platforms

Here is a quick rundown of our hand-picked top 10 HIPAA-compliant eSignature platforms: Signeasy, Docusign, PandaDoc, Dropbox Sign, Adobe Acrobat Sign, Jotform Sign, Xodo Sign (formerly Eversign), airSlate SignNow, SignWell, and Signaturely.

The table below compares their key features, pricing, and HIPAA compliance capabilities at a glance.

Comparison of top 10 HIPAA-compliant eSignature platforms (2026)
Features Signeasy DocuSign PandaDoc Dropbox Sign Adobe Acrobat Sign Jotform Sign Xodo Sign airSlate SignNow SignWell Signaturly
HIPAA compliance ✓ (with BAA add-on) ✓ (Enterprise) ✓ (Enterprise) ✓ (with BAA) ✓ (with BAA) ✓ (Gold and Enterprise)
Audit trails
Multi-factor authentication (2FA)
Reusable templates Limited Limited
Bulk send / Automation ✓ (add-on)
API access ✓ (Enterprise) ✓ (Enterprise) ✓ (Enterprise)
AI capabilities ✓ (summaries, key terms, QA) ✓ (limited) ✓ (add-on) ✓ (summarizer)
EHR / Healthcare integration ✓ (BAA support)
In-person signing ✓ (offline on mobile/tablet)
Mobile experience ✓ (full workflow + biometric login)
AI on mobile
Security Certifications SOC 2, HIPAA, GDPR, eIDAS, ESIGN/UETA ISO 27001, SOC 2 SOC 2, GDPR GDPR SOC 2, ISO 27001 SOC 2, GDPR SOC 2, GDPR SOC 2, HIPAA SOC 2 SOC 2
Tamper-proof trust seal
Team collaboration / roles Limited
Contract repository ✓ (centralized storage + analytics)
Custom branding
Ease of use ✓✓✓ ✓✓ ✓✓ ✓✓✓ ✓✓✓ ✓✓ ✓✓✓ ✓✓ ✓✓✓ ✓✓
Support 24/7 email + priority (Business Pro) Tiered Tiered Standard Tiered Standard Standard Tiered Standard Standard
Starting price (Dec 2025) $10/user $10/user $19/user $15/user $14.99/license $34/user $10/user $2/user $10/user $25/user
HIPAA compliant eSignature

Managing HIPAA-compliant eSignature processes doesn’t have to be overwhelming. With the right platform, healthcare professionals can say goodbye to all that tedious paperwork while making sure they stay compliant with the Health Insurance Portability and Accountability Act (HIPAA). 

In healthcare, where every second counts, modern tools like Electronic signature (eSignature) solutions make things easier by streamlining workflows, minimizing errors, and protecting patient data.

Imagine freeing your team from hours of scanning, faxing, and filing so they can focus on delivering top-notch care. HIPAA-compliant eSignature solutions enhance productivity and empower patients to complete forms digitally, right from their phones or computers.

Below, we’ve rounded up what HIPAA is and its privacy rule, top 10 HIPAA-compliant electronic signature platforms, and share best practices for their use. Let’s dive in and simplify healthcare, one eSignature at a time!

Top 10 HIPAA compliant eSignature platforms: A quick overview 

Here’s a quick rundown of our favorite top 10 HIPAA-compliant eSignature platforms. We’ve taken a close look at all the options out there, considering what really matters to you. Our review covers factors like how easy they are to use, security features, pricing, product integrations, and what other customers think. We hope this helps you find the perfect fit for your needs. 

  1. Signeasy
  2. Docusign
  3. PandaDoc
  4. Dropbox Sign
  5. Adobe Acrobat Sign
  6. Jotform Sign
  7. Xodo Sign
  8. airSlate SignNow
  9. SignWell
  10. Signaturely

Before we get into the details, let’s first understand what is HIPAA. 

What is HIPAA?

The Health Insurance Portability and Accountability Act (HIPAA) is a U.S. federal law established in 1996 to protect patients' personal health information (PHI). It applies to healthcare providers, health plans, clearinghouses, and their business partners who handle sensitive patient data.

HIPAA creates a framework that keeps health information secure while allowing healthcare professionals to share necessary details for quality care. The law covers several critical areas:

  1. Privacy of health information: National standards protect medical records and PHI. The Privacy Rule sets strict limits on using and disclosing information without patient consent.
  2. Security of electronic health information: The Security Rule requires administrative, physical, and technical safeguards to protect electronic protected health information (ePHI). Electronic signature software for healthcare must meet these security standards to handle patient documents compliantly.
  3. Enforcement: The Department of Health and Human Services (HHS) Office for Civil Rights investigates violations and imposes penalties for non-compliance.

How exactly does this law protect you? We turn now to the HIPAA Privacy Rule.

What is the HIPAA Privacy Rule?

The HIPAA Privacy Rule serves as the foundation for healthcare compliance in the United States. Introduced in 2002 as part of the HIPAA Act, it establishes how healthcare providers, insurers, and covered entities can manage and share Protected Health Information (PHI).

Visual guide to HIPAA's core principles: privacy, security, and alerts
Understanding HIPAA — protecting patient privacy and data security
Source

The Privacy Rule gives patients control over their health data. Healthcare providers must explain how PHI will be used and grant patients the right to access or amend their records. The rule also requires strict agreements with third-party vendors — like billing services or document processors — to maintain compliance standards.

Where do HIPAA-compliant eSignature solutions fit in?

HIPAA acknowledges that electronic transactions, including digital signatures, are essential for modern healthcare operations.

  • Secure electronic signature software with encryption and detailed audit trails protects PHI during electronic exchanges. These eSignature tools for healthcare streamline patient consent forms, treatment authorizations, and insurance claims without compromising privacy. 
  • According to a Journal of Medical Internet Research (JMIR) 2025 study, 61.3% of Americans accessed patient portals over the last 12 months, with 89.9% using them to view test results. 
  • The Privacy Rule allows healthcare organizations to adopt electronic signature software for healthcare while maintaining patient confidentiality. Healthcare providers benefit from faster workflows, better patient experiences, and stronger data protection across the board.

So, what's at stake when you digitize patient workflows?

Why HIPAA-compliant eSignature matters

Healthcare organizations face mounting pressure to digitize workflows while protecting sensitive patient data. Paper-based processes create bottlenecks (delayed patient onboarding, hours spent on administrative tasks, and increased risk of document loss or unauthorized access).

HIPAA-compliant eSignature solutions address these challenges by securing Protected Health Information (PHI) during critical transactions:

  • Patient consent forms
  • Treatment authorizations
  • Insurance agreements
  • Telehealth intake documents

The legal framework supports this shift. Both the ESIGN Act and UETA recognize electronic signatures as legally binding, and HIPAA explicitly permits their use when part of valid authorization processes.

ESIGN and UETA compliance ensures legal validity of eSignatures
eSignatures are legally binding under ESIGN and UETA acts

Healthcare providers can adopt eSignature tools without compromising compliance.

What’s the business impact?

  • Faster patient intake and reduced waiting room delays
  • Lower administrative costs and better staff productivity
  • Treatment authorizations that once took days now process in minutes
  • Patients can sign forms from their phones before appointments

But here's the catch: not all eSignature platforms meet HIPAA standards. Generic solutions lack the security safeguards, audit capabilities, and Business Associate Agreements (BAAs) required for healthcare use.

The difference between compliant and non-compliant tools can mean the difference between streamlined operations and costly violations.

Your platform checklist starts with these eight essential requirements.

HIPAA and eSignature — what are the requirements?

HIPAA doesn't explicitly mandate electronic signatures, but any eSignature solution handling PHI must comply with both the Privacy Rule and Security Rule. Healthcare organizations need platforms that meet specific technical, administrative, and physical safeguards.

Here's what HIPAA requires from electronic signature software for healthcare:

1. Business Associate Agreement (BAA)

Any vendor handling PHI qualifies as a business associate under HIPAA. The law requires a signed BAA outlining the vendor's data protection responsibilities. Without one, using an eSignature platform for healthcare documents creates immediate compliance violations. 

Most providers offer BAAs, but often only on specific plan tiers.

2. Data encryption

Secure your ePHI with SSL/TLS encryption for data in transit

ePHI must be encrypted both in transit and at rest. Look for:

  • In transit: TLS 1.2 or higher (256-bit encryption)
  • At rest: AES-256 encryption for stored documents

3. Access controls

The Security Rule requires strict controls over who can view, edit, or sign documents. Compliant platforms must provide:

  • Role-based access control (RBAC) limiting permissions by job function
  • Unique user identification with individual login credentials
  • Automatic session timeout after inactivity
  • Multi-factor authentication (2FA)

4. Comprehensive audit trails

HIPAA requires detailed logging of all activities involving ePHI. Platforms must record:

  • User identity, email, and IP address
  • Timestamps for views, edits, and signatures
  • Document changes and modifications
  • Device and location information

Audit trails must be tamper-proof and retained for at least six years.

5. Identity verification

Securing documents with Two-step Verification for signers

Platforms must verify signer identity through methods like:

  • Multi-factor authentication (password + SMS or email code)
  • Knowledge-based authentication (security questions)
  • Biometric verification (fingerprint, facial recognition)

6. Document integrity protection

Compliant platforms use digital certificates, tamper-evident seals, and cryptographic hash values to detect any post-signature alterations.

7. Security certifications and updates

Choose vendors who maintain current certifications (SOC 2 Type II, ISO 27001) and conduct regular security audits, vulnerability assessments, and penetration testing.

8. Patient rights and consent

Solutions must support clear consent language, allow patients to decline electronic signing, and provide easy access to signed document copies.

To choose securely, you need a process. Let’s review how to choose a HIPAA-compliant platform.

How to choose a HIPAA-compliant eSignature platform

Selecting the right platform requires more than checking a compliance box. Healthcare organizations need to evaluate specific capabilities that protect PHI while supporting efficient workflows.

Step 1. Start with the Business Associate Agreement (BAA)

If a vendor won't sign a BAA, move on. The agreement legally binds them to HIPAA standards and clarifies their responsibilities for protecting patient data.

Step 2. Verify encryption standards

Look for TLS 1.2 or higher for data in transit and AES-256 for data at rest. Ask vendors directly about their encryption protocols — vague answers are red flags.

Step 3. Examine authentication options

Multi-factor authentication should be standard, not optional. Platforms offering biometric verification, knowledge-based authentication, or integration with your existing SSO provide stronger identity verification.

Step 4. Review audit trail capabilities

Detailed logs tracking who accessed, viewed, and signed documents are required. Check that audit trails are tamper-proof and retained for at least six years.

Step 5. Check security certifications

SOC 2 Type II and ISO 27001 certifications indicate vendors undergo regular third-party security assessments. These aren't guarantees, but they show commitment to maintaining security standards.

Step 6. Assess integration capabilities

The platform should connect with your EHR system, cloud storage, and existing healthcare applications. Poor integration creates workflow gaps that introduce errors and security vulnerabilities.

Step 7. Evaluate vendor support and documentation

When compliance questions arise, responsive support matters. Review available resources, response times, and whether the vendor understands healthcare-specific requirements.

Time for the deep dive!

Detailed breakdown: Top 10 HIPAA-compliant eSignature platforms

We evaluated dozens of solutions to find platforms that balance security, usability, and healthcare-specific needs.

1. Signeasy

Signeasy stands out as a top HIPAA-compliant eSignature solution with robust security features, an intuitive interface, and strong regulatory compliance credentials.

Signeasy for HIPAA-compliant eSignatures in healthcare

Healthcare organizations trust it to handle sensitive patient documents while keeping workflows simple.

Take Truepill, for example. In the UK, where prescriptions traditionally depended on fax machines. Signeasy changed that entirely. Doctors now sign electronically in seconds without sacrificing due diligence.

"It's so easy for doctors to use, it hardly requires any training," says Shakil Ahmed, Managing Director at Truepill.

Also Read: 13 Best Docusign alternatives in 2026

The platform simplifies signing for both patients and healthcare staff while meeting strict HIPAA requirements. Advanced encryption, multi-factor authentication, and comprehensive audit trails protect PHI at every step. Regular security updates keep the system aligned with current regulations.

Features that stand out:

  • AI-powered contract insights: Signeasy's AI tools generate contract summaries, extract key terms automatically, and answer questions in natural language. 

Ask "When is the renewal date?" and get instant answers (even on mobile devices). All AI processing happens on secure servers with encrypted data handling.

  • Reusable templates with automation: Create standard templates for patient consent forms, medical orders, and insurance documents. Use dynamic tags like {{name}} and {{email}} to auto-populate fields. 

Pre-assign signing roles and sequences to eliminate manual setup for every document.

A 5-star review for Signeasy by Joshua N., praising templates
Signeasy review — streamlines new hire and client intake with templates
Source
  • Multi-factor authentication and biometric security: Verify user identity through password combinations, biometric verification (Face ID, Touch ID), and one-time passcodes.

Mobile users can authenticate quickly with fingerprint or facial recognition.

  • Comprehensive audit trails: Every transaction records timestamps, signer identity, IP addresses, device information, and document modifications.

Audit logs are tamper-proof and support compliance requirements for healthcare organizations.

Audit trail with document, fingerprint, and reference ID details
Audit trail showing document forensics and verification links
  • Seamless EHR integration: Connect directly with Electronic Health Records systems, Google Workspace, Microsoft tools (SharePoint, Outlook, Teams), and HubSpot. 

Documents flow between systems without compromising security or requiring staff to switch platforms.

  • Contract repository with powerful search: Store all signed documents in a centralized, secure repository. Advanced search tools help you locate specific contracts quickly.

Filter by status (Signed, Waiting, Completed) and track team activity for better oversight.

  • In-person signing on mobile: Collect signatures face-to-face using tablets or smartphones, even offline. Perfect for bedside consents or on-site patient intake. Signeasy syncs data once you're back online.

Try Signeasy for free!

2. Docusign

Docusign handles digital signing, document distribution, and workflow management for organizations that need enterprise-grade capabilities.

Streamline agreements for patient intake, staffing, and compliance

The platform connects with CRM systems, cloud storage services, and business applications healthcare organizations already use.

The interface balances functionality with usability, while security measures like encryption, multi-factor authentication, and detailed audit trails protect sensitive information. Docusign meets HIPAA requirements and maintains certifications for highly regulated industries.

Suggested Read: Signeasy vs. Docusign

Features that stand out:

  • Advanced security measures: Strong encryption protects PHI both in transit and at rest. Multi-factor authentication verifies user identities before granting access to documents, preventing unauthorized entry.
  • Global compliance certifications: Docusign holds HIPAA certification alongside ISO 27001 and SOC 2 Type II standards. These credentials demonstrate the platform's commitment to meeting international security requirements.
Docusign testimonial on solving slow, paper-based signing problems
Docusign review — praises efficiency, security, and digital workflow 
Source
  • Comprehensive audit trails: Every document generates a thorough audit trail with timestamps, identity verification records, and modification logs. This documentation helps healthcare organizations meet HIPAA's accountability requirements during audits.

3. PandaDoc

PandaDoc combines HIPAA-compliant eSignature capabilities with document management features.

PandaDoc landing page showing a 4.7-star rating and Leader badge
PandaDoc automates healthcare documents for faster patient care

The cloud-based platform handles document creation, distribution, and tracking with customizable templates, a drag-and-drop editor, and legally binding electronic signatures.

Multiple users can collaborate on documents simultaneously, adding comments and edits in real time. The platform connects with CRM systems, payment gateways, and business applications to automate workflows and reduce repetitive tasks.

Also Read: Signeasy vs. PandaDoc

Built-in analytics track document performance and recipient engagement, giving teams visibility into their processes.

Features that stand out:

  • Role-based access control: Administrators can set granular permissions for different users based on their roles. This minimizes unauthorized access risks to sensitive patient information.
  • Secure document storage with backups: Documents stay in access-controlled environments with regular backups. PHI remains protected against data loss and security breaches.
PandaDoc review praises effortless remote signing and organization
Source
  • Multi-factor authentication: Users verify their identity through multiple methods before accessing sensitive documents. Multi-factor authentication protects against unauthorized entry.
  • Customizable templates for compliance: Create and modify templates that meet specific HIPAA requirements. Healthcare teams can standardize consent forms, treatment authorizations, and administrative documents while maintaining compliance.

4. Dropbox Sign

Dropbox Sign (formerly HelloSign) offers secure electronic signature software that lets users sign, send, and manage documents online.

Dropbox Sign page demonstrating how to easily add a digital signature
Dropbox Sign makes sending and requesting eSignatures seamless

The platform eliminates printing and physical signatures while providing legally binding eSignatures, customizable templates, real-time tracking, and audit trails.

The solution connects with popular cloud storage services like Dropbox, Google Drive, and Microsoft OneDrive, plus other business applications. Integration is simple and fits seamlessly into existing workflows.

Dropbox Sign appeals to small and medium-sized healthcare practices that need straightforward, reliable eSignature tools for healthcare without complex setup.

Suggested Read: Signeasy vs. Dropbox Sign

Features that stand out:

  • HIPAA compliance with BAA: Dropbox Sign meets HIPAA privacy and security standards for handling PHI. The platform provides a Business Associate Agreement (BAA) to healthcare organizations, meeting legal and regulatory requirements for electronic signature software for healthcare.
Dropbox Sign review — simple way to collect patient consent forms
Source
  • Secure document storage: Signed documents stay in access-controlled environments with encryption protecting data against unauthorized access. The platform offers document retention policies and secure cloud storage options.
  • Multi-party signing workflows: Send documents to multiple signers in a specific order or simultaneously. Sequential signing works well for patient consent forms requiring signatures from patients, providers, and witnesses.

5. Adobe Acrobat Sign

Adobe Acrobat Sign provides cloud-based electronic signature capabilities for organizations that need enterprise-level document management.

Accelerate approvals with secure eSign capabilities in Acrobat
Adobe Acrobat Sign homepage

Part of the Adobe Document Cloud suite, it connects with Adobe Acrobat, Microsoft 365, and other business applications healthcare organizations use daily.

The platform combines strong security measures, industry compliance standards, and detailed tracking capabilities. Healthcare organizations can meet HIPAA requirements while reducing paper-based processes and improving document workflow efficiency.

Also Read: Signeasy vs. Adobe Acrobat Sign

Features that stand out:

  • Business Associate Agreement (BAA): Adobe provides a BAA for Acrobat Sign customers, a required document for organizations handling PHI under HIPAA regulations. Healthcare organizations can confidently use it as secure electronic signature software in regulated environments.
  • Data residency options: Control where your data is stored geographically. Data residency options give healthcare organizations additional oversight of data protection and help meet specific compliance requirements for HIPAA-compliant eSignature processes.
Acrobat Sign solves slow paper processes for quick, on-the-fly signing
Adobe Acrobat Sign — A trusted eSignature solution for enterprise
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  • Role-based access controls: Define specific permissions and limit access to sensitive documents based on user roles. Only authorized personnel can view or modify PHI, reducing the risk of unauthorized access.

6. Jotform Sign

Jotform Sign collects legally binding signatures directly within the Jotform platform. Users can create and manage documents requiring signatures without switching between different tools.

Jotform Sign — free eSignature software to automate your workflow
eSign documents in minutes using Jotform on any device

The feature works well for contracts, agreements, consent forms, and other documents needing formal approval.

Healthcare practices already using Jotform for patient intake forms can add signature collection to their existing workflows without additional complexity.

Features that stand out:

  • Drag-and-drop form builder: Add signature fields to existing forms using a simple drag-and-drop interface. The visual builder makes it straightforward to incorporate eSignatures into patient consent forms, treatment authorizations, and administrative documents.
  • Customizable templates: Pre-built templates designed for signature collection can be modified to match specific healthcare needs. Create standardized forms that maintain consistency across your organization.
  • Business Associate Agreement (BAA): Jotform provides a BAA to customers who need HIPAA-compliant eSignature capabilities, meeting legal requirements for eSignature tools for healthcare.
Jotform Sign offers templates and easy management for medical forms
Jotform Sign is HIPAA compliant and offers BAA
Source
  • Integrated document management: Manage signed documents within the Jotform platform. Download, print, or securely store completed forms for future reference and compliance audits.

7. Xodo Sign

Xodo Sign (formerly Eversign) is a cloud-based platform for creating, signing, and managing legally binding documents online.

Edit and eSign documents with Xodo tools, anytime, anywhere
Xodo offers secure document management and eSignature solutions

The solution serves businesses of all sizes with features that comply with international eSignature laws like the ESIGN Act and eIDAS.

Users can create and save templates for frequently used documents, then customize them for different purposes.Xodo Sign meets HIPAA regulations and is suitable as electronic signature software for healthcare organizations handling protected health information.

Also Read: Signeasy vs. Xodo Sign

Features that stand out:

  • Multi-party signing workflows: Send documents to multiple signers with defined signing order or allow simultaneous signing. Perfect for patient consent forms requiring signatures from patients, providers, and witnesses.
Clients satisfied with Xodo Sign's incredibly easy eSignature process
Xodo Sign makes the eSignature process faster and more efficient
Source
  • Extensive integration capabilities: Connect with Google Drive, Dropbox, Evernote, Salesforce, and other third-party applications. Workflow automation reduces manual document handling across different systems.
  • Custom branding options: Add your organization's logo and branding elements to documents and signature request emails. Maintain a professional, consistent appearance across all patient-facing materials.
  • Healthcare system integration: Xodo Sign connects with Electronic Health Records (EHRs) and practice management software. These integrations support compliant workflows and position it as reliable secure electronic signature software for healthcare environments.

8. airSlate SignNow

airSlate SignNow streamlines document signing, sending, and management as part of the airSlate Business Cloud.

SignNow facilitates HIPAA compliant eSign workflows for healthcare
SignNow delivers a better patient experience with HIPAA eSign

SignNow serves businesses across healthcare, finance, legal, and real estate with features built for efficiency, security, and compliance.

Suggested Read: Signeasy vs. SignNow

The platform provides legally binding electronic signatures that comply with the ESIGN Act and eIDAS. Signed documents are recognized and enforceable in courts and by regulatory bodies.

Features that stand out:

  • Intuitive interface: The platform's straightforward design lets users create, send, and sign documents quickly without technical training. Healthcare staff can start using the system with minimal onboarding time.
  • Full mobile accessibility: Dedicated iOS and Android apps allow users to sign and manage documents from anywhere. Providers can handle patient consent forms and treatment authorizations between appointments or during home visits.
  • Team collaboration tools: Teams can share and work on documents together with role-based access controls managing permissions. Healthcare departments can coordinate on patient documents while maintaining proper data security protocols for HIPAA-compliant eSignature workflows.
Review notes SignNow is easy to use, sharing, and field auto-detection
airSlate SignNow simplifies getting signatures and tracking contracts
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  • Advanced security measures: SSL/TLS encryption protects data during transmission and storage. Multi-factor authentication (MFA) adds another security layer, making it suitable as secure electronic signature software for organizations handling sensitive information.

9. SignWell

SignWell simplifies online document signing and management with strong eSignature functionality, reliable security measures, and regulatory compliance support.

SignWell for Healthcare — compliant eSignatures for practices and networks
SignWell handles patient forms, consent docs, and medical agreements

The platform provides a Business Associate Agreement (BAA) to customers requiring HIPAA compliance. Strong encryption methods protect sensitive information, while multi-factor authentication adds secure identity verification.

Features that stand out:

  • Intuitive interface: The straightforward design makes creating, sending, and signing documents simple for healthcare staff and patients. Users can complete signature requests without complicated steps or extensive training.
  • Strong security measures: SSL encryption protects data during transmission and storage. These security features make SignWell viable as secure electronic signature software for healthcare practices handling patient information.
  • Competitive pricing: SignWell provides essential eSignature features at an accessible price point. Smaller healthcare practices and clinics appreciate the cost-effectiveness without sacrificing necessary compliance capabilities.
SignWell is affordable and user-friendly for small business legal docs
SignWell offers an easy interface and helpful video support for users
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  • Detailed audit trails: Comprehensive audit logs track all document activities involving PHI. Records show who accessed, viewed, and signed documents with timestamps, supporting transparency requirements for HIPAA-compliant eSignature processes during compliance audits.
  • Automated reminders and notifications: The system sends automatic follow-ups to signers, reducing delays in completing consent forms and treatment authorizations. Healthcare teams spend less time chasing down signatures manually.

10. Signaturely

Signaturely provides legally binding electronic signatures that comply with global eSignature laws including the ESIGN Act and eIDAS.

Signaturely super simple eSignatures, legally signed blazing fast

Signed documents maintain validity and enforceability across jurisdictions. Users can create and save templates for frequently used documents, reducing repetitive work and maintaining consistency.

The platform supports multi-signature documents with sequential or simultaneous signing workflows for complex approval processes.

Features that stand out:

  • HIPAA-compliant data retention and deletion: Signaturely meets HIPAA requirements for secure retention and disposal of PHI. Users control how long documents are stored and when they're deleted, preventing PHI from remaining in the system longer than necessary for eSignature tools for healthcare.
Review highlights Signaturely's security and simplicity for client documents
Signaturely is secure, simple, and intuitive for all client signing
Source
  • Regular security audits: The platform undergoes regular security audits and assessments to maintain compliance. These evaluations verify that Signaturely continues meeting HIPAA's security and privacy standards as electronic signature software for healthcare organizations.
  • Cloud storage integrations: Connect with Google Drive, Dropbox, Box, and Microsoft OneDrive. Signed documents can be automatically stored in your organization's existing file management systems, keeping records organized and accessible for compliance reviews.

And that’s a wrap. Let's now talk about common mistakes and how to avoid them.

Avoiding risks and following best practices for HIPAA-compliant eSignatures

Non-compliant eSignature tools expose healthcare organizations to data breaches, legal penalties, and loss of patient trust.

According to the American Medical Association, HIPAA violation penalties range from $100 to $50,000 per violation, with annual maximums reaching $1.5 million per violation category. Here's how to protect your organization from common pitfalls:

Key risks and best practices for HIPAA-compliant eSignature workflows
Common risks with non-compliant eSignatures Best practices for HIPAA-compliant eSignatures
Weak identity verification exposes PHI to unauthorized access. Apply multi-factor authentication (MFA) using passwords, biometrics, or one-time codes to verify signers.
Missing audit trails make it difficult to prove consent or track signer actions. Keep detailed audit logs that record timestamps, IP addresses, and document versions for accountability.
Unencrypted files leave confidential health data vulnerable during transfer or storage. Use end-to-end encryption, so PHI stays protected in motion and at rest.
Vendors without BAAs put organizations at risk of HIPAA violations. Work with HIPAA-compliant vendors that sign a Business Associate Agreement (BAA).
Unsecured storage can expose documents to accidental leaks or access errors. Store signed records in access-controlled cloud environments with role-based permissions.
Limited staff awareness leads to unintentional breaches or mishandling of PHI. Provide regular HIPAA and security training to everyone handling digital documents.
No recovery plan causes workflow disruptions or data loss during outages. Maintain backup and recovery systems to preserve access and document integrity.

Bottom line: Choose vendors that understand healthcare requirements, respond quickly to compliance questions, and maintain current security certifications like SOC 2 Type II or ISO 27001.

Regular staff training on proper eSignature use and PHI handling reduces risk across your entire organization.

Here's proof that the right platform does make a difference.

Real-world eSignature use cases in healthcare and regulated industries

HIPAA-compliant platforms handle everything from telehealth consent to vendor contracts. Healthcare organizations across specialties rely on secure eSignature solutions to manage sensitive documentation while maintaining compliance.

Here are three examples showing how electronic signature software for healthcare works in practice.

Telehealth patient consent: Chupik Counseling

When Chupik Counseling transitioned to telemedicine during COVID-19, their paper-based patient consent process collapsed overnight. The Texas-based mental health practice with five locations needed patients to sign telehealth consent forms with HIPAA terms — without in-person visits.

 Signeasy case study — counseling practice transitions to telemedicine
Chupik Counseling transitions to telehealth with Signeasy

Signeasy replaced their print-and-bring system with digital templates sent via email. Patients now sign consent forms before appointments, and therapists automatically receive completed documents for immediate filing.

"We evaluated Docusign first but weren't happy with the feature-heavy platform," says Jeffrey Chupik, President and CEO. "Signeasy worked well for us with good pricing and just the right features we wanted."

High-volume treatment documentation: Camen Behavioral Services

Camen Behavioral Services creates approximately 300 individualized behavior plans every six months for children with disabilities — each 30 to 50 pages long. Previously, parents rushed through these critical documents at the office with children in tow and phones ringing.

Signeasy streamlines 300+ behavior plans for Camen Behavioral
Camen Behavioral boosts productivity by 90% with Signeasy

With HIPAA-compliant eSignature tools, parents now review plans at home and sign digitally. The change boosted productivity by 90% and eliminated massive paper waste. 

"We are audited for our paperwork, so we wanted an electronic streamlined way to house all these signatures," explains Kayleigh Guy, Program Director.

Regulatory documentation and board approvals: San Diego Eye Bank

The San Diego Eye Bank processes lab approvals, budgets, SOPs, and legal documents for organ transplant operations. Executive Director Dhore Anunciado previously commuted to the office just to sign paperwork.

Signeasy helps SDEB process lab approvals and legal documents fast
Signeasy enables San Diego Eye Bank to work and sign remotely

Microsoft Teams integration lets SDEB move entirely remote. "Signeasy allows us to work remotely without going into the office to sign a simple document," says Anunciado. "Our employees don't have to wait for me to physically sign a document to proceed."

That said, let's look back at our review of all ten platforms. Here's why Signeasy stands out.

Why Signeasy is the right HIPAA-compliant eSignature solution

Built for healthcare organizations that need security, speed, and scalability. Signeasy meets every HIPAA requirement while offering features designed specifically for healthcare workflows.

Signeasy offers secure, compliant eSignatures for healthcare providers
Signeasy safeguards data with AES and SSL 256-bit encryption

The platform provides signed Business Associate Agreements (BAAs), AES-128 encryption at rest, SSL 256-bit encryption in transit, and tamper-proof audit trails that track every document action with timestamps, IP addresses, and user details.

Healthcare organizations get more than basic compliance:

  • AI-powered contract insights generate summaries, extract key terms, and answer questions in natural language — (even on mobile and tablet).
  • Reusable templates with dynamic fields automate patient consent forms and treatment authorizations.
  • Centralized contract repository with advanced search helps teams locate documents instantly during audits.

The platform integrates directly with EHR systems, Microsoft tools (SharePoint, Outlook, Teams), Google Workspace, and HubSpot. Healthcare teams can sign documents without switching between applications.

Signeasy holds SOC 2 Type II certification and complies with GDPR, eIDAS, ESIGN/UETA, and 21 CFR Part 11 standards. For organizations needing custom workflows, the API enables seamless integration into existing healthcare systems.

You've seen the options — now it's time to take the next step.

Make your eSignatures HIPAA-friendly with Signeasy

Healthcare organizations need electronic signature software that protects patient data while improving operational efficiency.

The 10 HIPAA-compliant eSignature platforms we've covered all provide secure ways to handle critical documentation, but Signeasy offers distinct advantages for mid-sized to enterprise healthcare teams.

Signeasy combines HIPAA compliance with powerful features: AI-powered contract insights, reusable templates that automate repetitive workflows, comprehensive audit trails, and direct integration with EHR systems.

Healthcare staff and patients both benefit from an intuitive interface that requires minimal training.

The platform handles everything from telehealth consent forms to vendor contracts, treatment authorizations to insurance documents. Your team gets the security credentials healthcare requires (BAA, SOC 2 Type II, encryption standards) plus the productivity tools modern organizations demand.

Ready to see Signeasy in action? Request a demo or start your free trial today to experience HIPAA-compliant contract management built for mid-sized to enterprise healthcare organizations.

Frequently asked questions

What is a HIPAA-compliant electronic signature?
A HIPAA-compliant electronic signature refers to a digital signature solution that meets the requirements set forth by the Health Insurance Portability and Accountability Act (HIPAA) for handling and securing protected health information (PHI). HIPAA is a US law designed to ensure the privacy and security of healthcare data, and any platform that processes PHI, including electronic signatures, must adhere to strict compliance standards to prevent unauthorized access, loss, or misuse of this sensitive information.
Is Signeasy HIPAA compliant?
Yes, Signeasy is HIPAA compliant and meets the necessary security and privacy standards required for handling PHI.
Is Docusign HIPAA compliant?
Yes, Docusign is HIPAA compliant.
Is Adobe eSignature HIPAA compliant?
Yes, Adobe eSignature is HIPAA compliant.
Are all eSignature platforms HIPAA compliant?
No, not all eSignature platforms are HIPAA compliant. For an eSignature platform to be HIPAA compliant, it must meet the specific security and privacy standards required by HIPAA, such as encryption, audit trails, user authentication, and a signed Business Associate Agreement (BAA). Many popular eSignature platforms offer HIPAA-compliant features, but it's important to verify that the platform you choose provides these safeguards before using it to sign documents containing PHI.
What security features should a HIPAA-compliant eSignature platform have?
A HIPAA-compliant eSignature platform must have robust security features, such as end-to-end encryption (AES-256 or similar), multi-factor authentication (MFA) for user verification, role-based access controls to limit who can access or sign documents, and detailed audit trails to track all document interactions. These features help safeguard PHI and ensure that it is only accessed by authorized individuals.
How long should I retain documents with PHI in a HIPAA-compliant system?
HIPAA requires that PHI be retained for a specified period, typically six years, and that documents containing PHI are securely deleted when no longer needed. However, this rule may vary. Some states need PHI retention for seven years, and some states recommend up to 10 years. While OSHA mandates 30 years for certain records.
Rachana Chotia
Rachana Chotia
Rachana is the Content Marketing Manager at Signeasy, where she works with the product & customer teams to create content related to eSignature and contract workflows. In her free time, she enjoys going for walks, watching anime, and reading a good book.
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